Below please find a brief list of some of the presentations coming up today at the American Society of Tropical Medicine 62nd Annual Conference in Washington DC. Click links to view abstracts.
Rapid clearance of parasitemia by the novel spiroindolone KAE609 in a phase 2 open-label study of adults with acute, uncomplicated Plasmodium falciparum or vivax malaria mono-infection by Nicholas White et al.
In summary, when administered 30 mg daily for 3 days, KAE609 was well tolerated and achieved rapid parasite clearance in adult patients with uncomplicated P. vivax or P. falciparum malaria infection.
Symposium on Implementation of Mass Drug Administration for Malaria Control and Elimination. Symposium Organizer: Roly Gosling, Global Health Group, University of California, San Francisco, San Francisco
With the recognition that a large proportion of malaria infections are low density, below the level of detection by microscopy or Rapid Diagnostic Test, MDA is coming back into favor. The speakers will explore the drug choices available for MDA in different settings; for example, for P. falciparum settings in Haiti, The Gambia and the Artemsisinin Resistance Containment zone, and for P. vivax in Asia and the Pacific.
Innovative Field Tools for Detecting Counterfeit Medicines – The Case Study of Anti-Malarials. Symposium Organizer: JOEL BREMAN, FOGARTY INTERNATIONAL CENTER, NATIONAL INSTITUTES OF HEALTH
The need for innovative field tools for the detection of spurious/falsely-labelled/falsified/counterfeit medicines is becoming increasingly important, particularly in low-resource settings. A global public health crisis is looming, especially in malaria treatment and prevention, where up to 90 percent of antimalarials in surveys done in Asia and Africa are reported to be falsified or substandard.
Session: Malaria Epidemiology – Tracking Trends and Finding Foci, Village-level characteristics associated with spatial distributions of malaria-infected individuals in an area of Southern Zambia receiving mass screening and treatment by David A Larson et al.
Varying spatial distributions of malaria-infected individuals appear to be driven by vector abundance and gametocyte prevalence in the population. The ability to clearly delineate village malaria prevalence may assist in developing mechanisms for focused interventions to optimize their effectiveness.
Session: Malaria Epidemiology – Tracking Trends and Finding Foci. Reservoirs of asymptomatic malaria in Malawi: results of two cross-sectional studies by Jenny A. Walldorf et al.
In Malawi and potentially in other endemic settings, school age children represent important reservoirs of asymptomatic infection and should be targeted for interventions to interrupt transmission.
Session: Malaria Epidemiology – Tracking Trends and Finding Foci. Sustained Declining Burden of Malaria at Community level in Northeastern Tanzania. by Acleus S. Rutta et al.
The reported decline of malaria in most parts of Tanzania has some implication on accuracy of malaria diagnosis and management. The current remarkable and sustained decline in malaria suggests that these areas might be moving from control to pre-elimination levels.